Plague Ascendancy Guildrun relic icon
Epic relic · Demo 0.5.9

Plague Ascendancy

Quest: Inflict 25 Poison, 50 Frost, and 75 Burn on a single enemy. At start of Combat, inflict 25 Poison, 50 Frost, and 75 Burn on all enemies.

Demo 0.5.11 fix

Duplicate relic offers corrected

Freezing relics before Challenge Fights or the Auction House no longer allows duplicate relics.

Official patch notes ↗
Exact text

Quest and reward

Quest: Inflict 25 Poison, 50 Frost, and 75 Burn on a single enemy. At start of Combat, inflict 25 Poison, 50 Frost, and 75 Burn on all enemies.

Run check

How to evaluate it

This relic has a quest gate. Read the condition and the reward separately, then make sure the comp can complete the condition during a normal run.

Team fit

Heroes matched by class and mechanic

Search Plague Ascendancy guides ↗

Matches come from the relic text, class names, and hero keywords. They are not a win-rate tier list.

Community data

See Plague Ascendancy in a full comp

Check formations and written guides for the rest of the team, items, and positioning.

Plague Ascendancy buildsPlague Ascendancy guides